王晓磊

联系方式

  • 职  称:beat365教授,博士生导师
  • 联系电话:
  • 邮  箱:wangxiaolei@lzu.edu.cn

兰州大学萃英特聘教授、博士生导师,甘肃省陇原人才,国家青年人才计划入选者。2006 年获得兰州大学化学基地班学士学位,2011 年获得兰州大学有机化学博士学位,师从厍学功教授。2011-2015 年,在美 UT Southwestern Medical Center 从事博士后研究,师从 Chuo Chen 教授,开展吡咯 - 氨基咪唑天然产物不对称全合成研究;2015-2017 年,在 The Scripps Research Institute 从事研究助理工作,师从 Chi-Huey Wong 教授,开展以 Transglycosylase 为靶点的新型抗生素研发。迄今 Science、J. Am. Chem. Soc.、JMC 等国际著名刊物上合作发表学术论文 20 余篇。

主持青年基金单萜吲哚生物碱 strictamine、picrinine 及 aspidophylline 的全合成及其生物活性研究 (2018-2020 );

主持面上项目核苷类天然产物 A201A/A201E 合成及其构效关系研究(2021-2024)。

1.“Enantioselective α‑Functionalization of 1,3-Dithianes by Iridium-Catalyzed Allylic Substitution”. Wang,PP.;Jiang Q, Zhao RB, Xie XG,* Tang SC,* and Wang XL*J. Org. Chem. 2020, 85, 12456−12467.

2.“Dithiane-Induced [3+2] Cycloaddition Tactic for the Convergent Synthesis of Dihydropyrrole and Pyrrole Derivatives” Jia HB.; Min D.; Guo TY.; Wu MZ.; Wang XL.; * Liu J.; * and Tang SC* J. Org. Chem. 2020, 85, 14847−14857.

3.“Visible-light promoted dithioacetalization of aldehydes with thiols under aerobic and photocatalyst-free conditions”.Xing,ZM.; Yang,MY.; Sun HY.;  Wang ZM.; Chen P.; Liu L.; Wang XL.;* Xie XG *.; She XG. Green Chem., 2018, 20, 5117.

4. “Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor”. Special issue: Dale Boger: A Celebration of 65 Years of Excellence. Wang, X.; Krasnova, L.; Wu, K. B.; Wu. S.; Cheng, T.; Wong, C-H.* Bioorg. Med. Chem. Lett., 2018, 28, 2708.

5.“Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence”. Ma, Z.; Wang, X.; Wang, X.; Gao, S.; Tan, X.; Ma, Y.; Lynch, V. M.; Chen, C. Science (Co-first auhor,Highlighted in C&EN News) 2014, 346, 219.

6. “Syntheses of Sceptrins and Nakamuric Acid and Insights into the Biosyntheses of Pyrrole–Imidazole Dimers”. Wang, X.; Gao, Y.; Ma, Z.; Rodriguez, R. A.; Yu, Z.-X.; Chen, C. Org. Chem. Front. 2015,2, 978.